Featured publications
Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells
January 9, 2023
Johnston R, Mathias B, Crowley SJ, Schmidt HA, White LS, Mosammaparast N, Green AM, Bednarski JJ. Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells. EMBO Rep. 2023 Jan 9;24(1):e55429. doi: 10.15252/embr.202255429. Epub 2022 Nov 16. PMID: 36382770; PMCID: PMC9827558.
Assessing DNA Damage Responses Using B Lymphocyte Cultures
March 16, 2022
Johnston R, White LS, Bednarski JJ. Assessing DNA Damage Responses Using B Lymphocyte Cultures. Methods Mol Biol. 2022;2444:69-80. doi: 10.1007/978-1-0716-2063-2_5. PMID: 35290632.
DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
June 22, 2020
Collins PL, Purman C, Porter SI, Nganga V, Saini A, Hayer KE, Gurewitz GL, Sleckman BP, Bednarski JJ, Bassing CH, Oltz EM. DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner. Nat Commun. 2020 Jun 22;11(1):3158. doi: 10.1038/s41467-020-16926-x. PMID: 32572033; PMCID: PMC7308414.
RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex
October 22, 2019
Soodgupta D, White LS, Yang W, Johnston R, Andrews JM, Kohyama M, Murphy KM, Mosammaparast N, Payton JE, Bednarski JJ. RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex. Cell Rep. 2019 Oct 22;29(4):829-843.e5. doi: 10.1016/j.celrep.2019.09.026. PMID: 31644907; PMCID: PMC6870970.
Recent publications
- MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaksMathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, LM. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
- Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B CellsChakraborty, M., Greenberg, Z. J., Dong, Q., Roundy, N., Bednarski, J. J., Paracatu, L. C., Duncavage, E., Li, W. & Schuettpelz, L. G., Apr 1 2024, In: Journal of Immunology. 212, 7, p. 1075-1080 6 p.Research output: Contribution to journal › Article › peer-review
- Pediatric Necrobiotic Xanthogranuloma as a Novel Phenotype of IKAROS Gain of FunctionGuess, R., Harocopos, G., Bednarski, J. J., Hassmann, L. M. & Bigley, T. M., Jan 2024, In: Journal of Clinical Immunology. 44, 1, 19.Research output: Contribution to journal › Letter › peer-review
- Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark studyEissa, H., Thakar, M. S., Shah, A. J., Logan, B. R., Griffith, L. M., Dong, H., Parrott, R. E., O'Reilly, R. J., Dara, J., Kapoor, N., Forbes Satter, L., Chandra, S., Kapadia, M., Chandrakasan, S., Knutsen, A., Jyonouchi, S. C., Molinari, L., Rayes, A., Ebens, C. L., Teira, P., & 38 othersDávila Saldaña, B. J., Burroughs, L. M., Chaudhury, S., Chellapandian, D., Gillio, A. P., Goldman, F., Malech, H. L., DeSantes, K., Cuvelier, G. D. E., Rozmus, J., Quinones, R., Yu, L. […]
- Genotype, oxidase status, and preceding infection or autoinflammation do not affect allogeneic HCT outcomes for CGDLeiding, J. W., Arnold, D. E., Parikh, S., Logan, B., Marsh, R. A., Griffith, L. M., Wu, R., Kidd, S., Mallhi, K., Chellapandian, D., Si Lim, S. J., Grunebaum, E., Falcone, E. L., Murguia-Favela, L., Grossman, D., Prasad, V. K., Heimall, J. R., Touzot, F., Burroughs, L. M., Bleesing, J., & 49 othersKapoor, N., Dara, J., Williams, O., Kapadia, M., Oshrine, B. R., Bednarski, J. J., Rayes, A., Chong, H., Cuvelier, G. D. E., Forbes Satter, L. R., Martinez, C., Vander Lugt, M. T., Yu, […]
- Steroid-Responsive Pulmonary Hypertension in a Pediatric Patient with Chronic Granulomatous Disease and HistoplasmosisSLCH Consortium, Aug 2023, In: Journal of Clinical Immunology. 43, 6, p. 1118-1121 4 p.Research output: Contribution to journal › Letter › peer-review
- Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment ConsortiumThakar, M. S., Logan, B. R., Puck, J. M., Dunn, E. A., Buckley, R. H., Cowan, M. J., O'Reilly, R. J., Kapoor, N., Satter, L. F., Pai, S. Y., Heimall, J., Chandra, S., Ebens, C. L., Chellapandian, D., Williams, O., Burroughs, L. M., Saldana, B. D., Rayes, A., Madden, L. M., Chandrakasan, S., & 45 othersBednarski, J. J., DeSantes, K. B., Cuvelier, G. D. E., Teira, P., Gillio, A. P., Eissa, H., Knutsen, A. […]
- Hematopoietic KIT D816Y mutation presenting as in utero aggressive systemic mastocytosis with response to midostaurinVoelker, D., Bednarski, J. J., Nieman, E., Carter, M. C. & Polk, B., Apr 2023, In: Journal of Allergy and Clinical Immunology: In Practice. 11, 4, p. 1323-1325.e1Research output: Contribution to journal › Article › peer-review
- The diagnosis of severe combined immunodeficiency: Implementation of the PIDTC 2022 DefinitionsDvorak, C. C., Haddad, E., Heimall, J., Dunn, E., Cowan, M. J., Pai, S. Y., Kapoor, N., Satter, L. F., Buckley, R. H., O'Reilly, R. J., Chandra, S., Bednarski, J. J., Williams, O., Rayes, A., Moore, T. B., Ebens, C. L., Davila Saldana, B. J., Petrovic, A., Chellapandian, D., Cuvelier, G. D. E., & 31 othersVander Lugt, M. T., Caywood, E. H., Chandrakasan, S., Eissa, H., Goldman, F. D., Shereck, E., Aquino, V. M., Desantes, K. B., Madden, L. M., Miller, H. K., Yu, L., Broglie, L., Gillio, A., […]
- Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cellsJohnston, R., Mathias, B., Crowley, S. J., Schmidt, H. A., White, L. S., Mosammaparast, N., Green, A. M. & Bednarski, J. J., Jan 9 2023, In: EMBO Reports. 24, 1, e55429.Research output: Contribution to journal › Article › peer-review