Featured publications
Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells
January 9, 2023
Johnston R, Mathias B, Crowley SJ, Schmidt HA, White LS, Mosammaparast N, Green AM, Bednarski JJ. Nuclease-independent functions of RAG1 direct distinct DNA damage responses in B cells. EMBO Rep. 2023 Jan 9;24(1):e55429. doi: 10.15252/embr.202255429. Epub 2022 Nov 16. PMID: 36382770; PMCID: PMC9827558.
Assessing DNA Damage Responses Using B Lymphocyte Cultures
March 16, 2022
Johnston R, White LS, Bednarski JJ. Assessing DNA Damage Responses Using B Lymphocyte Cultures. Methods Mol Biol. 2022;2444:69-80. doi: 10.1007/978-1-0716-2063-2_5. PMID: 35290632.
DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner
June 22, 2020
Collins PL, Purman C, Porter SI, Nganga V, Saini A, Hayer KE, Gurewitz GL, Sleckman BP, Bednarski JJ, Bassing CH, Oltz EM. DNA double-strand breaks induce H2Ax phosphorylation domains in a contact-dependent manner. Nat Commun. 2020 Jun 22;11(1):3158. doi: 10.1038/s41467-020-16926-x. PMID: 32572033; PMCID: PMC7308414.
RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex
October 22, 2019
Soodgupta D, White LS, Yang W, Johnston R, Andrews JM, Kohyama M, Murphy KM, Mosammaparast N, Payton JE, Bednarski JJ. RAG-Mediated DNA Breaks Attenuate PU.1 Activity in Early B Cells through Activation of a SPIC-BCLAF1 Complex. Cell Rep. 2019 Oct 22;29(4):829-843.e5. doi: 10.1016/j.celrep.2019.09.026. PMID: 31644907; PMCID: PMC6870970.
Recent publications
- Antiviral cellular therapy for enhancing T-cell reconstitution before or after hematopoietic stem cell transplantation (ACES): a two-arm, open label phase II interventional trial of pediatric patients with risk factor assessmentKeller, M. D., Hanley, P. J., Chi, Y. Y., Aguayo-Hiraldo, P., Dvorak, C. C., Verneris, M. R., Kohn, D. B., Pai, S. Y., Dávila Saldaña, B. J., Hanisch, B., Quigg, T. C., Adams, R. H., Dahlberg, A., Chandrakasan, S., Hasan, H., Malvar, J., Jensen-Wachspress, M. A., Lazarski, C. A., Sani, G. & Idso, J. M. & 29 others, Lang, H., Chansky, P., McCann, C. D., Tanna, J., Abraham, A. A., Webb, […]
- Novel EXTL3 Variants Causing Neuro-Immuno-Skeletal DysplasiaWash U./N. I. H. EXTL3 Consortium, Dec 2024, In: Journal of Clinical Immunology. 44, 8, 188.Research output: Contribution to journal › Letter › peer-review
- Letermovir as cytomegalovirus prophylaxis in children undergoing allogeneic hematopoietic cell transplantationPfeiffer, T., Lockowitz, C. R., Shenoy, S., Mavers, M., Hayashi, R., Bednarski, J. & Green, A., Aug 2024, In: Bone Marrow Transplantation. 59, 8, p. 1193-1195 3 p.Research output: Contribution to journal › Letter › peer-review
- The SMC5/6 complex prevents genotoxicity upon APOBEC3A-mediated replication stressFingerman, D. F., O’Leary, D. R., Hansen, A. R., Tran, T., Harris, B. R., DeWeerd, R. A., Hayer, K. E., Fan, J., Chen, E., Tennakoon, M., Meroni, A., Szeto, J. H., Devenport, J., LaVigne, D., Weitzman, M. D., Shalem, O., Bednarski, J., Vindigni, A., Zhao, X. & Green, A. M., Aug 1 2024, In: EMBO Journal. 43, 15, p. 3240-3255 16 p.Research output: Contribution to journal › Article › peer-review
- Cytokines drive the formation of memory-like NK cell subsets via epigenetic rewiring and transcriptional regulationFoltz, J. A., Tran, J., Wong, P., Fan, C., Schmidt, E., Fisk, B., Becker-Hapak, M., Russler-Germain, D. A., Johnson, J., Marin, N. D., Cubitt, C. C., Pence, P., Rueve, J., Pureti, S., Hwang, K., Gao, F., Zhou, A. Y., Foster, M., Schappe, T. & Marsala, L. & 9 others, Berrien-Elliott, M. M., Cashen, A. F., Bednarski, J. J., Fertig, E., Griffith, O. L., Griffith, M., Wang, T., Petti, A. A. & Fehniger, T. A., Jun 28 2024, In: Science immunology. 9, 96, eadk4893.Research output: Contribution to […]
- Allogeneic hematopoietic cell transplantation is effective for p47phox chronic granulomatous disease: A Primary Immune Deficiency Treatment Consortium studyGrunebaum, E., Arnold, D. E., Logan, B., Parikh, S., Marsh, R. A., Griffith, L. M., Mallhi, K., Chellapandian, D., Lim, S. S., Deal, C. L., Kapoor, N., Murguía-Favela, L., Falcone, E. L., Prasad, V. K., Touzot, F., Bleesing, J. J., Chandrakasan, S., Heimall, J. R., Bednarski, J. J. & Broglie, L. A. & 21 others, Chong, H. J., Kapadia, M., Prockop, S., Dávila Saldaña, B. J., Schaefer, E., Bauchat, A. L., Teira, P., Chandra, S., Parta, M., Cowan, M. J., Dvorak, C. C., […]
- MYSM1 attenuates DNA damage signals triggered by physiologic and genotoxic DNA breaksMathias, B., O'Leary, D., Saucier, N., Ahmad, F., White, L. S., Russell, L. M., Shinawi, M., Smith, M. J., Abraham, R. S., Cooper, M. A., Kitcharoensakkul, M., Green, A. M. & Bednarski, J. J., Apr 2024, In: Journal of Allergy and Clinical Immunology. 153, 4, p. 1113-1124.e7Research output: Contribution to journal › Article › peer-review
- Cutting Edge: The Tetraspanin CD53 Promotes CXCR4 Signaling and Bone Marrow Homing in B CellsChakraborty, M., Greenberg, Z. J., Dong, Q., Roundy, N., Bednarski, J. J., Paracatu, L. C., Duncavage, E., Li, W. & Schuettpelz, L. G., Apr 1 2024, In: Journal of Immunology. 212, 7, p. 1075-1080 6 p.Research output: Contribution to journal › Article › peer-review
- Relevance of lymphocyte proliferation to PHA in severe combined immunodeficiency (SCID) and T cell lymphopeniaAbraham, R. S., Basu, A., Heimall, J. R., Dunn, E., Yip, A., Kapadia, M., Kapoor, N., Satter, L. F., Buckley, R., O'Reilly, R., Cuvelier, G. D. E., Chandra, S., Bednarski, J., Chaudhury, S., Moore, T. B., Haines, H., Dávila Saldaña, B. J., Chellapandian, D., Rayes, A. & Chen, K. & 37 others, Caywood, E., Chandrakasan, S., Lugt, M. T. V., Ebens, C., Teira, P., Shereck, E., Miller, H., Aquino, V., Eissa, H., Yu, L. C., Gillio, A., Madden, L., Knutsen, A., Shah, A. J., DeSantes, K., […]
- Posttransplantation late complications increase over time for patients with SCID: A Primary Immune Deficiency Treatment Consortium (PIDTC) landmark studyEissa, H., Thakar, M. S., Shah, A. J., Logan, B. R., Griffith, L. M., Dong, H., Parrott, R. E., O'Reilly, R. J., Dara, J., Kapoor, N., Forbes Satter, L., Chandra, S., Kapadia, M., Chandrakasan, S., Knutsen, A., Jyonouchi, S. C., Molinari, L., Rayes, A., Ebens, C. L. & Teira, P. & 38 others, Dávila Saldaña, B. J., Burroughs, L. M., Chaudhury, S., Chellapandian, D., Gillio, A. P., Goldman, F., Malech, H. L., DeSantes, K., Cuvelier, G. D. E., Rozmus, J., Quinones, R., […]